(£) GBP (Default)
  • ($) USD
  • (€) EUR
  • ($) AUD
  • ($) CAD
  • ($) NZD
Pharma Lab Global

15% off first order with code: 1storder

Pharma Lab Global
99%+ Quality Guaranteed
Pharma Lab Global

Competitive Prices

Pharma Lab Global
Shipping Protection
Pharma Lab Global
Fast Order Process

Buy AICAR

What is AICAR Peptide?

AICAR peptide, is also known as 5-Aminoimidazole-4-carboxamide ribonucleotide. It is a significant biochemical compound recognized for its role as an activator of AMP-activated protein kinase (AMPK). This activation is crucial as AMPK serves as a key regulator of energy homeostasis within cells [1].

By stimulating AMPK, AICAR enhances the cellular uptake of glucose and increases the oxidation of fatty acids, making it a valuable tool in metabolic research.

The applications if AICAR extend into potential therapeutic areas, where it is studied for its ability to mimic exercise effects, offering hope for treatments in metabolic disorders such as diabetes and obesity, and contributing to improved cardiovascular health [2].

Molecular Formula: C9H15N4O8P

Molecular Weight: 338.21 g/mol

Source:  PubChem

Buy AICAR
AICAR Peptide Vial

Summary of AICAR Benefits:

Buy AICAR Peptide Vial here – Available in 50 mg vials here.

The Mechanism of Action of AICAR Latvia

AICAR peptide acts primarily by activating AMP-activated protein kinase (AMPK), a central enzyme in cellular energy regulation. AMPK activation occurs when AICAR is converted into ZMP (5-aminoimidazole-4-carboxamide ribotide) within cells, mimicking AMP’s effect on AMPK.

This activation triggers a cascade of biochemical pathways that enhance energy homeostasis. Specifically, AMPK shifts the cell’s metabolism from energy consumption to energy production by increasing glucose uptake and fatty acid oxidation. It facilitates glucose transport into cells, promoting glycolysis and thereby providing immediate energy [3].

Concurrently, by enhancing fatty acid oxidation, AMPK reduces lipid accumulation, contributing to lower body fat levels. These metabolic adjustments make AICAR a promising candidate for treating metabolic disorders such as diabetes and obesity.

By mimicking exercise effects, AICAR offers therapeutic potential for individuals unable to engage in physical activity, supporting cardiovascular health and metabolic disease management.

Buy AICAR Nasal Spray Latvia from PharmaLabGlobal offering a painless peptide delivery to your clinical research. Choose from 15ml or 30 ml ready to use peptide clear solution.

Buy AICAR Peptide

Potential Clinical Applications of AICAR Latvia

Enhances cellular energy levels

AICAR improves energy levels in the body primarily by activating AMP-activated protein kinase (AMPK), a key enzyme involved in energy regulation. Once AICAR is converted into ZMP within the cells, it mimics the effects of AMP, leading to the activation of AMPK. This activation triggers a series of metabolic changes that enhance energy metabolism [1].

AMPK activation increases glucose uptake by the cells, boosting glycolysis and rapidly producing ATP, the cell’s main energy currency. Additionally, AMPK enhances the oxidation of fatty acids, breaking down stored fats to provide further energy. This dual action not only increases immediate energy availability but also helps in reducing fat accumulation, promoting a leaner body composition.

Improves the metabolism

AMPK plays a crucial role in cellular energy regulation, and its activation triggers several downstream effects that facilitate increased glucose uptake.

One of the key mechanisms is the upregulation of glucose transporter proteins, such as GLUT4, which translocate to the cell membrane, allowing more glucose to enter the cell. This process is pivotal for improving glucose uptake, especially in muscle and adipose tissues. Once inside the cell, glucose undergoes glycolysis, a metabolic pathway that breaks down glucose to produce ATP, the primary energy currency of the cell.

By boosting glucose uptake and enhancing glycolysis, AICAR effectively increases cellular energy levels. This mechanism is particularly beneficial for metabolic health, offering potential therapeutic advantages for conditions like diabetes, where glucose regulation is impaired [4].

Reduces body fat

By the activation of AMPK fatty acid oxidation is enhanced, a process where stored fats are broken down into fatty acids and converted into energy. By promoting the use of fats as an energy source, AICAR shifts energy metabolism from storage to utilization, thereby reducing fat accumulation [5].

Additionally, AMPK activation influences lipid metabolism by inhibiting the synthesis of new fatty acids and promoting the breakdown of existing fats. This results in decreased lipid storage and an overall reduction in body fat.

Promotes cardiovascular health

By activating AMPK, AICAR improves endothelial function, which is vital for maintaining healthy blood vessels. This enhancement leads to better vascular relaxation and blood flow, reducing the risk of hypertension and atherosclerosis.

Furthermore, AICAR enhances lipid metabolism by increasing fatty acid oxidation, which helps lower triglyceride levels and prevent the accumulation of harmful lipids in the bloodstream. This process aids in maintaining a healthy lipid profile, crucial for cardiovascular health [5].

AICAR also plays a role in reducing inflammation, a key factor in the development of cardiovascular diseases. By dampening inflammatory pathways, it mitigates the risk of plaque formation and arterial blockages [6].

Reduces inflammation

When AMPK is activated by AICAR, it influences several inflammatory pathways, leading to a reduction in inflammation. One of the key mechanisms involves the inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway, a primary regulator of inflammatory responses. By suppressing NF-κB activity, AICAR reduces the expression of pro-inflammatory cytokines and mediators, which are often elevated in inflammation-related conditions [7].

Additionally, AMPK activation modulates other pathways, such as the downregulation of mTOR signalling, which is associated with inflammatory processes. These actions collectively help in diminishing chronic inflammation and may offer therapeutic benefits for conditions like arthritis, cardiovascular diseases, and metabolic disorders that involve inflammation as a central feature.

Buy AICAR Pre-Mixed Peptide Pen Latvia. Complete pen kits and pre-mixed refill cartridges supplied by PharmaLabGlobal for research purposes.

AICAR Nasal Spray 15ml

Is AICAR approved for human consumption?

AICAR is not currently approved by the FDA for therapeutic use. It has been used in limited human investigations but currently remains unapproved for general medical applications.

FAQ’s about AICAR Latvia

What is the difference between AICAR and AMPK peptides?

AICAR and AMPK peptides are related but distinct in their roles and functions:

AICAR: AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a compound that acts as an activator of AMPK (AMP-activated protein kinase). It mimics AMP, binding to the γ subunit of AMPK, which leads to the enzyme’s activation. This activation helps increase energy availability by promoting the usage of fat for energy [8].

AMPK: AMPK itself is an enzyme that plays a crucial role in cellular energy homeostasis. It is activated in response to low energy levels in the cell, leading to increased energy production and decreased energy consumption. AMPK activation results in various physiological effects, such as enhancing glucose uptake and fatty acid oxidation.

In summary, AICAR is a compound used to activate AMPK, while AMPK is the enzyme that regulates energy balance within cells. Discover the AMPK Peptide here.

Scientific Research

[1] Hall DT, Griss T, Ma JF, Sanchez BJ, Sadek J, Tremblay AMK, Mubaid S, Omer A, Ford RJ, Bedard N, Pause A, Wing SS, Di Marco S, Steinberg GR, Jones RG, Gallouzi IE. The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting. EMBO Mol Med. 2018 Jul;10(7):e8307. 

[2] Choksey A, Carter RD, Thackray BD, Ball V, Kennedy BWC, Ha LHT, Sharma E, Broxholme J, Castro-Guarda M, Murphy MP, Heather LC, Tyler DJ, Timm KN. AICAR confers prophylactic cardioprotection in doxorubicin-induced heart failure in rats. J Mol Cell Cardiol. 2024 Jun;191:12-22. 

[3] Richter EA, Derave W, Wojtaszewski JF. Glucose, exercise and insulin: emerging concepts. J Physiol. 2001 Sep 1;535(Pt 2):313-22. 

[4] Kjøbsted R, Hingst JR, Fentz J, Foretz M, Sanz MN, Pehmøller C, Shum M, Marette A, Mounier R, Treebak JT, Wojtaszewski JFP, Viollet B, Lantier L. AMPK in skeletal muscle function and metabolism. FASEB J. 2018 Apr;32(4):1741-1777.

[5] Gaidhu MP, Frontini A, Hung S, Pistor K, Cinti S, Ceddia RB. Chronic AMP-kinase activation with AICAR reduces adiposity by remodeling adipocyte metabolism and increasing leptin sensitivity. J Lipid Res. 2011 Sep;52(9):1702-11.

[6] Alfaddagh A, Martin SS, Leucker TM, Michos ED, Blaha MJ, Lowenstein CJ, Jones SR, Toth PP. Inflammation and cardiovascular disease: From mechanisms to therapeutics. Am J Prev Cardiol. 2020 Nov 21;4:100130. 

[7] Staniland AA, Clark AK, Wodarski R, Sasso O, Maione F, D’Acquisto F, Malcangio M. Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice. J Neurochem. 2010 Aug;114(4):1143-57. 

[8] Višnjić D, Lalić H, Dembitz V, Tomić B, Smoljo T. AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review. Cells. 2021 May 4;10(5):1095

Further Reading:

The Potential Role of Peptides in Diabetes Management

This blog discusses the potential role of peptides in diabetes management. It highlights how peptides like MOTS-c, AMPK, AICAR, and FTPP can influence metabolic pathways, improve insulin sensitivity, and enhance glucose homeostasis. These peptides offer innovative therapeutic options by targeting underlying biochemical processes, providing hope for improved diabetes care and outcomes.

Unlocking Cellular Energy with AICAR Nasal Spray Peptide

Explore the benefits of AICAR Nasal Spray Peptide in this blog, and its role in enhancing cellular energy by activating the AMPK pathway. Discover potential health benefits, including improved metabolic function, cardiovascular health, neuroprotection, and anti-inflammatory effects, making it a promising therapeutic tool in the future for various health conditions.

Exploring the Profound Nature of NAD+ Peptide and its Role in Enhancing Metabolic Functions

Discover the role of NAD+ peptide in enhancing metabolic functions. It highlights NAD+’s involvement in cellular energy production, DNA repair, and sirtuin activation, which contribute to improved metabolic efficiency, energy levels, and cognitive function. AICAR and NAD+ potential benefits for diabetes management and overall health are also discussed, emphasizing its significance in promoting longevity and well-being.

Why Buy AICAR from PharmaLabGlobal?

Premium Quality Peptides

Peptides are manufactured to a purity standard of 99% (complex peptides are 98% pure or higher)

Global Supplier

At Pharma Lab Global we supply premium peptides to the research industry worldwide.

Excellent Customer Service

Our mission and priority are to ensure that clients receive a superior customer experience.

Competitive Prices

At Pharma Lab Global we aim to supply the highest purity research peptides at affordable prices.

ALL PRODUCT INFORMATION AND ARTICLES ON THIS SITE ARE FOR EDUCATIONAL PURPOSES ONLY

DISCLAIMER: All products sold by Pharma Lab Global are for research and laboratory use only. These products are not designed for use or consumption by humans or animals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such. By purchasing from our Website the buyer accepts and acknowledges the risks involved with handling of these products. All articles and product information provided on this Website are for informational and educational purposes only. Handling and use of these products should be restricted to suitably qualified professionals.