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What is PT-141 Peptide?

PT-141 Peptide, also known as Bremelanotide, is a synthetic peptide that functions as a melanocortin receptor agonist. It is primarily recognized for its potential in treating sexual dysfunction, specifically hypoactive sexual desire disorder (HSDD) in both men and women [1].

PT-141 works by activating melanocortin receptors in the brain, which play a role in regulating sexual arousal and desire. Unlike traditional treatments like Viagra that target blood flow, PT-141 acts on the central nervous system to enhance libido. This peptide is believed to have a direct impact on the brain’s pathways involved in sexual response, offering a novel approach to addressing intimacy-related concerns [2].

Molecular Formula: C50H68N14O10

Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-OH

Molecular Weight: 1025.2 g/mol

View the HPLC Certificate here.

Source: PubChem

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Peptide PT-141 Benefits:

Buy PT-141 Peptide Vial here – Available 10mg vials

PT-141 Mechanism of Action

According to Latvia clinical studies PT-141 Peptide, or Bremelanotide, exerts its mechanism of action primarily by targeting melanocortin receptors in the brain. Upon administration, PT-141 binds to these receptors, particularly the melanocortin 4 receptor (MC4R), which plays a crucial role in regulating sexual function and behaviour. By activating MC4R, PT-141 stimulates pathways involved in sexual arousal and desire, leading to an increase in libido [2].

Furthermore, PT-141’s mechanism differs from traditional treatments for sexual dysfunction like PDE5 inhibitors (e.g., Viagra), which primarily enhance blood flow to facilitate erections. Instead, PT-141 acts centrally on the central nervous system, influencing the brain circuits responsible for sexual response. This unique approach sets PT-141 apart as a novel therapeutic option for addressing intimacy-related concerns.

The activation of melanocortin receptors by PT-141 is believed to modulate neurotransmitter release, particularly dopamine, a key player in the brain’s reward system and pleasure responses. By enhancing dopamine signaling, Latvia scientists believe that PT-141 may further contribute to heightened sexual motivation and satisfaction. Overall, PT-141’s mechanism of action offers a promising avenue for individuals experiencing hypoactive sexual desire disorder (HSDD) to potentially regain and enhance their sexual interest and experiences [1].

Buy PT-141 Peptide Nasal Spray from PharmaLabGlobal Latvia offering a painless peptide administration via nasal delivery for clinical subjects.

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Future Clinical Applications of PT-141 Peptide

PT-141, also known as Bremelanotide, is a synthetic peptide derived from the popular Melanotan 2 peptide. Furthermore, PT-141 is a melanocortin that primarily binds to the MC-4R and MC-1R receptors, currently a research peptide, it is hoped in the future it could offer a therapeutic treatment for the following:

Hypoactive Sexual Desire Disorder

PT-141 peptide stimulates sexual desire and arousal in individuals with hypoactive sexual desire disorder (HSDD) through its unique mechanism of action. Latvia Research has found that by targeting melanocortin receptors in the brain, particularly the melanocortin 4 receptor (MC4R), PT-141 triggers pathways involved in sexual response. This activation leads to an increase in libido and heightened sexual arousal, addressing the underlying lack of sexual desire characteristic of HSDD [1].

Unlike traditional treatments that focus on physiological aspects like blood flow on erectile function, PT-141 acts centrally on the central nervous system to enhance sexual motivation and pleasure. By modulating neurotransmitter release, especially dopamine, PT-141 may amplify feelings of sexual desire and reward, contributing to a more fulfilling sexual experience for individuals with HSDD. This targeted approach of PT-141 offers a promising solution for those seeking to rekindle their sexual interest and responsiveness [2].

Alternative to Viagra 

PT-141 presents potential advantages over Viagra for individuals with cardiovascular issues due to its unique mechanism of action. Unlike Viagra, which primarily targets blood flow to aid in achieving and maintaining erections, researchers have found that PT-141 nasal spray acts centrally on the brain’s melanocortin receptors to enhance sexual desire and arousal. This distinction is crucial for individuals with cardiovascular concerns, as PT-141’s mechanism does not directly impact cardiovascular function or blood pressure in the same way as Viagra [3].

For those with cardiovascular issues, the safety profile of PT-141 may be more favourable, as it avoids the systemic effects associated with vasodilators like Viagra. By focusing on neural pathways rather than vascular responses, PT-141 offers a targeted approach to addressing sexual dysfunction without posing additional risks to cardiovascular health. This makes PT-141 a potentially safer and more suitable option for individuals dealing with both sexual concerns and cardiovascular conditions [4].

Haemorrhagic Shock

PT-141’s potential in treating haemorrhagic shock is linked to its ability to influence blood pressure regulation and vascular function. In Latvia preclinical studies, PT-141 has demonstrated vasopressor effects, meaning it can constrict blood vessels and increase blood pressure. This property could be beneficial in managing haemorrhagic shock, a condition characterized by severe blood loss and low blood pressure. By potentially enhancing vascular tone and blood pressure, PT-141 may help stabilize circulation and improve perfusion to vital organs, thereby offering a novel approach to support hemodynamic stability in individuals experiencing haemorrhagic shock. Further research is needed to explore the full extent of PT-141’s therapeutic benefits in this context.

Buy PT-141 Pre-Mixed Peptide Pen. PharmaLabGlobal Latvia supplies pen kits and pre-mixed refill cartridges for research purposes.

Where can I buy PT-141?

High purity PT-141 can be purchased online from PharmaLab Global for clinical trial use only. In some countries PT-141 has not yet been approved for human consumption by the FDA so it is imperative to check the legalities of where the shipping address lies.

PT-141 FAQ's

Is PT-141 an aphrodisiac? 

PT-141, also known as Bremelanotide, is a peptide that has been studied for its potential aphrodisiac effects. It works by activating melanocortin receptors in the brain, which may lead to increased sexual arousal and desire. Latvia Clinical trials have shown promising results in both men and women with certain forms of sexual dysfunction, suggesting that PT-141 can have aphrodisiac-like properties.

What are the side effects associated with PT-141?

Some potential side effects associated with the human use of PT-141 injection (Bremelanotide) may include nausea, flushing, headaches, and increased blood pressure. In some cases, individuals have reported darkening of the skin, particularly in moles or freckles. It’s important to note that these side effects can vary in severity and occurrence among users. As with any medication or peptide, it is advisable to consult with a healthcare provider before using PT-141 to understand its potential risks and dosage for your specific health circumstances.

Can PT-141 help premenopausal women?

PT-141 (Bremelanotide) has shown potential benefits for premenopausal women experiencing sexual dysfunction, including issues such as low libido or arousal difficulties. Clinical studies have suggested that PT-141 may help improve sexual desire and satisfaction in women with certain forms of sexual dysfunction. 

Buy PT-141 Kisspeptin Peptide Combo

The Kisspeptin and PT-141 combo could potentially offer complementary benefits in addressing sexual dysfunction. Kisspeptin, known for its role in initiating puberty and regulating reproductive function, may enhance the sensitivity of the reproductive system to sexual stimuli. When combined with PT-141, which stimulates sexual desire and arousal through central nervous system pathways, the synergistic effects could lead to a more comprehensive improvement in libido, sexual response, and overall sexual satisfaction.

This combination therapy may provide a multi-faceted approach to treating various forms of sexual dysfunction by targeting both physiological and neurological aspects of sexual function simultaneously.

Scientific Research

[1] Edinoff AN, Sanders NM, Lewis KB, Apgar TL, Cornett EM, Kaye AM, Kaye AD. Bremelanotide for Treatment of Female Hypoactive Sexual Desire. Neurol Int. 2022 Jan 4;14(1):75-88.

[2] Molinoff PB, Shadiack AM, Earle D, Diamond LE, Quon CY. PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Ann N Y Acad Sci. 2003 Jun;994:96-102. 

[3] Diamond LE, Earle DC, Garcia WD, Spana C. Co-administration of low doses of intranasal PT-141, a melanocortin receptor agonist, and sildenafil to men with erectile dysfunction results in an enhanced erectile response. Urology. 2005 Apr;65(4):755-9. 

[4] Mohammad Reza Safarinejad and Seyyed Yousof Hosseini, Salvage of Sildenafil Failures With Bremelanotide: A Randomized, Double-Blind, Placebo Controlled Study, The Journal of Urology, Volume 179, Issue 3, March 2008, Page: 1066-1071


Further Reading:

Tanning with Peptides

Delve into the fascinating world of tanning with peptides, exploring how these innovative compounds can revolutionize your approach to achieving a sun-kissed glow.

Discover the science behind peptides like Melanotan 2 and PT-141 and their potential role in enhancing melanin production, leading to a deeper and longer-lasting tan. 

Discover more about Tanning Peptides and their link to PT-141 here.

PT-141 and Kisspeptin Revolutionizing Sexual Disorder Treatment

We explore how PT-141 and Kisspeptin are reshaping the landscape of sexual disorder treatment.

This blog delves into the mechanisms of action of these peptides, highlighting their pivotal roles in enhancing libido, arousal, and overall sexual satisfaction. 

Read about the future of sexual health through the lens of PT-141 and Kisspeptin.

What is the Best Peptide Stack?

This comprehensive guide explores the synergistic effects of various peptide stacks, highlighting how specific combinations can enhance muscle growth, aid in recovery, boost cognitive function, and support overall well-being.

By delving into the science behind peptide synergy and offering insights into effective stack formulations.

Read more about Peptide Stacks here.

Why Buy PT-141 from PharmaLabGlobal?

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Peptides are manufactured to a purity standard of 99% (complex peptides are 98% pure or higher)

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